Megalith may refer to any of the following:
- Megalith (facility), the Erusean weapon of mass destruction that had the capability to shoot down asteroids in orbit
- Megalith (mission), the 18th and final campaign mission in Ace Combat 04: Shattered Skies, dedicated to destroying this facility
- Operation Judgement Day, the final ISAF operation of the Continental War, dedicated to destroying this facility
- Megalith defense squadron, the squadron defending this facility during Operation Judgement Day
- Twinkle Islands, the island chain upon which this facility was built
- Fortress Intolerance, a facility that featured many similarities to the Megalith facility
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